The feasibility of opal/high dose Ara-C treatment of adult acute lymphoblastic leukaemia.

نویسندگان

  • M J Barnett
  • A Z Rohatiner
  • M A Richards
  • J H Waxman
  • T S Ganesan
  • A Miller
  • R Biruls
  • T A Lister
چکیده

Studies conducted at St. Bartholomew's Hospital between 1972 and 1982 into the treatment of acute lymphoblastic leukaemia (ALL) in adults showed a complete remission (CR) rate of 65% (73/112) using a combination of vincristine, prednisolone, adriamycin, and L-asparaginase, with. CR frequency being highest in young patIents and lowest in those with L3 morphology. The duration of remission correlated closely with blast cell count at presentation and the surface phenotype of the blas.t cells, ~e­ ing significantly longest in patIents ~lth low blast counts of common ALL antIgen (CALLA) positivity. Central nervous system (CNS) relapse alone was relatively frequent in those patients in who.n:'the cerebrospinal fluid (CSF) was poslt~ve at t.he first lumbar puncture (3/13) despIte cramospinal or cranial irradiation and intrathecal therapy. However, by far the greatest pro?lem was bone marrow relapse alone, or m association with relapse at other sites, e.g. CSF, testis, skin (43/53) and was not reduced by introducing escalati~g ~oses of adriamycin and cyclophosphamIde mto the early therapy [1]. . Recent experience with the use of hIgh dose cytosine arabinoside (Ara-C) in the treatment of both ALL in relapse and the lymphoid blast crisis of chr?nic ~yeloid leukaemia has been encouragmg wIth a response being achieved in 9/14 patients af-

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A single high dose of idarubicin combined with high-dose ARA-C (MSKCC ALL-3 protocol) in adult and pediatric patients with acute lymphoblastic leukemia. Experience at the University "La Sapienza" of Rome.

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عنوان ژورنال:
  • Haematology and blood transfusion

دوره 29  شماره 

صفحات  -

تاریخ انتشار 1985